Q&A #1
Ask me anything!
Happy Memorial Day and welcome back!
Starting this month, May 2025, I’m going to be doing monthly Q&A’s here on Substack as an extra perk for paid subscribers (check out my full catalog of free and exclusive posts if you’re new around here).
To participate, simply leave a comment below with your question and I’ll do my best to answer. Questions can be about anything; not just science, biology, and supplements, but random topics as well if you wish. I’ll answer any question asked before the next month’s Q&A post.
Rules:
1 question per person per Q&A, although 1-2 follow up questions are allowed
“Thoughts on xyz…” is not a question
Do not ask for medical advice
Ask good questions. The better the question, the better my answer will be
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Disclaimer: None of the answers provided below should be taken as medical advice. Any and all content on this Substack is for educational purposes only. BowTiedNeuron is not a licensed medical professional. Always consult your doctor before making any major health decisions.
I have seen/ read at a few places Selegiline is good for longevity, is that the case? I thought it was a Parkinson’s drug — does it have any downstream effects on brain health?
Is there any mechanisms by which inhibition in the nervous system can lower testosterone / dht?
Still in puberty with a goal of keeping testosterone high but need to manage my nervous system
I struggle with insomnia / anxiety and so need heavy NMDA antagonism, and to modulate gaba / glutamate otherwise I risk relapsing into insomnia its bad
The stack I currently take daily is: 1.5g elemental magnesium, 3g agmatine, 1g carnosine and 4g inositol, this keeps me very calm, albeit focus is lowered and libido lowers a lot , along with aggression lowered ( which makes me fear its affecting my androgens). I've tried lowering dosages but anything less than this and I relapse into severe isssues
I do everything for high testosterone, nutrient dense diet, sprints 3x a week, fat intake, sleep / stress is good when aided by pharmacology, still get morning wood every morning, and exercise recovery is good but like I just still fear a lot with ocd / health anxiety that my hormones may be getting reduced due to the low libido / aggression / lowered focus.
I know testosterone increases intracelluear calcium, motor neuron firing, but would modulating these nervous system features directly affect T as a backwards mechanism. I search into google and see some studies stuff saying gaba can inhibit gnrh, but it seems very unclear.
Tldr: Happy to feel calm, low focus, lowered aggression, less stereotypically 'androgenic'; but would androgens still remain high keeping its affects on bone growth eg via androgen receptor.